2020-02-24 02:07 There are two types of COX enzymes, COX1 and COX2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever; however, only COX1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining. NSAIDs block the COX enzymes and reduce production of prostaglandins.
In the 1990s, researchers discovered that two different COX enzymes existed, now known as COX1 and COX2. Cyclooxygenase1 (COX1) is known to be present in most tissues. In the gastrointestinal tract, COX1 maintains the normal lining of the stomach. cox 1 and 2 difference
Pharmacology. In terms of their molecular biology, COX1 and COX2 are of similar molecular weight, approximately 70 and 72 k Da, respectively, and having 65 amino acid sequence homology and nearidentical catalytic sites. The most significant difference between the isoenzymes, which allows for selective inhibition,
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COX2 is phylogenetically more primitive that COX1 and, while very similar, has critical differences, particularly the existence of a small pocket half way down the active enzyme site. A number of drugs achieve selectivity by binding to this pocket, including presumptively rofecoxib and celecoxib. On the other hand COX2 is an inducible enzyme as it is produced under certain specific conditions like inflammation. Difference in Locations: COX1 is commonly found in the kidney, stomach and platelets whereas COX2 is located in macrophages, leukocytes and fibroblasts. COX2, on the other hand, is primarily found at sites of inflammation. Both COX1 and COX2 produce the prostaglandins that contribute to pain, fever, and inflammation, but since COX1's primary role is to protect the stomach and intestines and contribute to blood clotting, using drugs that inhibit it can lead to unwanted side effects. cox 1 and 2 difference (Proceedings) COX2 is also involved in cellular processes including gene expression, differentiation, mitogenesis, apoptosis, bone modelling, wound healing and neoplasia. A new isoform, COX3, has also been discovered in the brain. It appears to be a derivative of COX1,
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