Extracellular matrix elasticity directs stem cell differentiation

2020-02-27 19:49 Extracellular matrix (ECM) is a dynamic and complex environment characterized by biophysical, mechanical and biochemical properties specific for each tissue and able to regulate cell behavior. Stem cells have a key role in the maintenance and regeneration of tissues and they are located in a specific microenvironment, defined as niche.

Sep 28, 2015 Extracellular Matrix. ECM is the physical scaffold synthesized by cells. Cells elaborate their ECM by secreting proteins, and in turn, the ECM regulates cell behavior and influences the remodeling of their matrix. 11, 12 This relationship between cells and ECM was proposed as dynamic reciprocity by Bornstein et al in 1982. extracellular matrix elasticity directs stem cell differentiation

In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometrytopography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell.

J Musculoskelet Neuronal Interact 2007; 7(4): 335. Hylonome. Stem cell differentiation is regulated by a variety of cues including growth factors and extracellular matrix (ECM), although the role that the ECM has in this process is less under stood. extracellular matrix elasticity directs stem cell differentiation

Extracellular matrix elasticity directs stem cell differentiation Article in Journal of musculoskeletal& neuronal interactions 7(4): 335 October 2007 with 108 Reads Source: PubMed Aug 25, 2006 Matrix elasticity directs stem cell lineage specification. During the initial week in culture, reprogramming of these lineages is possible with addition of soluble induction factors, but after several weeks in culture, the cells commit to the lineage specified by matrix elasticity, consistent with the commitment Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anticorrelates with stiffness, and has a low elastic modulus (E 1 kPa), making extracellular matrix elasticity directs stem cell differentiation Matrix Elasticity Directs Stem Cell Lineage Specification. Adam J. Engler a desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation. Dev. Biol. 1995; 172: . Any starting point for such approaches must include characterization of the mechanosensitivity of the stem cell of interest to matrix Human MSCs were the first stem cells used to demonstrate the in vitro influence of matrix stiffness on stem cell differentiation. To test mechanosensitive lineage specification of MSCs, PA gel formulations to mimic the tissue stiffness of brain, muscle, and osteoid (bone surface) were used. Matrix elasticity directs stem cell lineage Spatially patterned matrix elasticity directs stem cell fate Chun Yanga, b, Frank W. DelRioc, Hao Mab, d, derstanding of the role of extracellular matrix organization on disease, aging, and regenerative processes. Spatially patterned matrix elasticity directs stem cell fate

Video Extracellular matrix elasticity directs stem cell differentiation

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